施明研究组
施明 教授
发布时间:2021年02月04日
浏览次数:

施明,博士,教授,博士生导师。担任肿瘤生物治疗国家地方联合工程实验室副主任,江苏省肿瘤生物治疗工程实验室主任。主要从事肿瘤免疫治疗研究,主持国家自然基金面上项目4项、青年项目1项、国家863项目子课题1项、国家重大新药创制项目子课题1项、江苏省重点研发计划项目等课题。以第一或通讯作者发表SCI论文27篇,累计IF 162分,被引用802次。其中IF大于5分19篇。参编国外学术专著两部、译著两部。获国家发明专利3项。获军队科技进步一等奖(2014年,排名第二)、中国抗癌协会科技奖三等奖(2014年,排名第二)。指导研究生获省级优秀硕士学位论文奖2项。2017年入选江苏省“双创人才”,2018年入选江苏省特聘医学专家。担任中国生物医药技术协会临床应用专业委员会委员、中国病理生理学会免疫学专业委员会委员、中国生理学会应用生理学专业委员会委员,中华医学会医学细胞生物学会青年委员会委员。

代表论文:

1.Blockade of AIM2 inflammasome or α1-AR ameliorates IL-1β release and macrophage-mediated immunosuppression induced by CAR-T treatment. J Immunother Cancer. 2021 Jan;9(1):e001466.

2.CRISPR screen in mechanism and target discovery for cancer immunotherapy. Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188378.

3.β2-AR Activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells. Cancer Sci. 2020 Dec;111(12):4417-4428.

4.Neural regulation of drug resistance in cancer treatment. Biochim Biophys Acta Rev Cancer, 2019, 1871(1):20-28.

5.Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre-metastatic niche through activating β-adrenergic signaling. J Pathol, 2018, 244(1):49-60.

6.Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model. Brain Behav Immun, 2016, 57:243-54.

7.β2-AR signaling controls trastuzumab resistance-dependent pathway. Oncogene. 2016. 35(1):47-58.

8.Catecholamine-induced β2-AR activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. J Immunol. 2013, 190:5600-5608

9.Glucocorticoid regulation of a novel HPV E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells. J Pathol. 2012, 228:148-157.

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