柴大飞，医学博士，美国贝勒医学院博士后/Instructor,现为徐州医科大学副教授，硕士生导师，江苏省高校“青蓝工程”中青年学术带头人，主要从事肿瘤抗体、疫苗靶向治疗及其作用机制研究。在此领域获得国家自然科学基金项目2项、江苏省自然科学基金青年项目1项、江苏省教育厅重点研发项目1项、徐州市重点研发计划项目1项的支持。截止目前为止，在J Hematol Oncol、Blood、Mol Cancer、Mol Ther、J Immunother Cancer、Cancer Lett、NPJ Vaccines、Pharmacol Res等专业期刊发表SCI论文55篇。其中以第一作者或通讯作者身份发表30篇。授权国家发明专利6项。获得中华医学科技奖二等奖，江苏医学科技奖一等奖，并指导本科生获得2024年“大创”国家级项目，2021年第十七届“挑战杯”江苏省选拔赛三等奖等荣誉称号。目前担任J Hematol Oncol、Mol Ther、Pharmacol Res、Frontier in immunology等杂志客座编辑或审稿人。
代表论文：
1.Dafei Chai#*, Junhao Wang#, Chunmei Fan, Jing-Ming Lim, Xu Wang, Praveen Neeli, Xinfang Yu, Ken H Young, Yong Li*. Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant.J Hematol Oncol. 2024, 17(1): 45. (IF: 29.5)
2.Dafei Chai#*, Junhao Wang#, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li*. Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity.Mol Cancer. 2025, 24(1): 12. (IF: 27.7)
3.Dafei Chai, Yong Li*. Expanding nucleic acid-encoded medicine.Mol Ther. 2025, 33(1):16-17. (IF: 12.1)
4.Dafei Chai#*, Xu Wang#, Chunmei Fan, Junhao Wang, Jing Ming Lim, Xinfang Yu, Ken H Young, Yong Li*. Vaccines targeting p53 mutants elicit anti-tumor immunity.Cancer Lett. 2024, 611: 217421. (IF: 9.1)
5. Yanyan Zheng, Jiawei Wang, Guangya Zhao, Zichun Zhang, Yingxiang Shao, Bowen Lu, Yuchen Zhang, Renjin Chen, Li Sun, Xiaohui Xie, Jiage Ding*, Junnian Zheng*,Dafei Chai*. Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma.J Immunother Cancer. 2025, 13(1):e010521. (IF: 10.3)
6. Fei Zhu, Zheng Lu, Wenjing Tang, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Lin Fang, Huizhong Li, Gang Wang, Renjin Chen*, Junnian Zheng*,Dafei Chai*. Adenovirus vaccine targeting kinases induces potent antitumor immunity in solid tumors.J Immunother Cancer. 2024, 12(8): e009869. (IF: 10.3)
7. Bowen Lu, Leizi Chai, Zichun Zhang, Guangya Zhao, Yingxiang Shao, Yanyan Zheng, Xin Jin, Junnian Zheng*,Dafei Chai*, Jiage Ding*. Co-immunization with IFI35 enhances the therapeutic effect of an adenovirus vaccine against renal carcinoma.Int J Biol Macromol. 2025, 286:138515. (IF: 7.7)
8. Nan Jiang, Yanyan Zheng, Jiage Ding, Jiawei Wang, Fei Zhu, Meng Wang, Navid Sobhani, Praveen Neeli, Gang Wang, Hailong Li*, Junnian Zheng*,Dafei Chai*. The co-delivery of adenovirus-based immune checkpoint vaccine elicits a potent anti-tumor effect in renal carcinoma.NPJ Vaccines. 2023, 8(1):109. (IF: 6.9)
9.Dafei Chai#*, Xu Wang#, Praveen Neeli, Shan Zhou, Xingfang Yu, Kanaga Sabapathy, Yong Li*. DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice.Genes Dis. 2023, 11(4): 100994. (IF: 6.9)
10. Jiage Ding, Yanyan Zheng, Gang Wang, Junnian Zheng*,Dafei Chai*. The performance and perspectives of dendritic cell vaccines modified by immune checkpoint inhibitors or stimulants.Biochim Biophys Acta Rev Cancer. 2022, 1877(5):188763. (IF: 9.9)
11. Jiage Ding, Nan Jiang, Yanyan Zheng, Jiawei Wang, Lin Fang, Huizhong Li, Jie Yang, Ankang Hu, Pengli Xiao, Qing Zhang,Dafei Chai*, Junnian Zheng*, Gang Wang*. Adenovirus vaccine therapy with CD137L promotes CD8+DCs-mediated multifunctional CD8+T cell immunity and elicits potent anti-tumor activity.Pharmacol Res. 2022, 175:106034. (IF: 9.1)
12. Yanyan Zheng, Zheng Lu, Fei Zhu, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Gang Wang, Lin Fang, Junnian Zheng*,Dafei Chai*. Therapeutic vaccine targeting dual immune checkpoints induces potent multifunctional CD8+T cell anti-tumor immunity.Int Immunopharmacol. 2024, 142(Pt A):113004. (IF: 4.8)
13. Bowen Lu, Jing Ming Lim, Boyue Yu, Siyuan Song, Praveen Neeli, Navid Sobhani, Pavithra K, Srinivasa Reddy Bonam, Rajendra Kurapati, Junnian Zheng*,Dafei Chai*. The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects.Front Immunol. 2024, 15:1332939. (IF: 5.7)
14. Jiage Ding, Yanyan Zheng, Fei Zhu, Meng Wang, Lin Fang, Huizhong Li, Hui Tian, Yong Liu, Gang Wang*, Junnian Zheng*,Dafei Chai*. Adenovirus-assembled DC vaccine induces dual-targeting CTLs for tumor antigen and adenovirus to eradicate tumors.Int Immunopharmacol. 2023, 123:110722. (IF: 4.8)
15. Xiaoqing Shi, Jiage Ding, Yanyan Zheng, Jiawei Wang, Navid Sobhani, Praveen Neeli, Gang Wang*, Junnian Zheng*,Dafei Chai*. HMGB1/GPC3 dual targeting vaccine induces dendritic cells-mediated CD8+T cell immune response and elicits potential therapeutic effect in hepatocellular carcinoma.iScience. 2023, 26(3):106143. (IF: 4.6)
