肿瘤疫苗子方向负责人
chaidafei@xzhumu.edu.cn
柴大飞，医学博士，副教授，硕士生导师，江苏省“青蓝工程”中青年学术带头人，主要从事肿瘤疫苗及肿瘤免疫逃逸机制的研究。现负责徐州医科大学江苏省肿瘤生物治疗研究所人源化抗体工程项目。先后获得及主持国家自然科学基金2项、省部级课题2项，市厅级重点课题1项，徐州医科大学优秀人才科研启动基金1项，在MolecularCancer therapeutics、CancerScience等杂志发表SCI论文18篇，其中以第一作者发表SCI论文10篇。申请国家发明专利2项。目前担任Int Immunopharmacol、Transl Oncol等杂志特邀审稿人。
代表论文
1.Dafei Chai, Zichun Zhang, Nan Jiang, Jiage Ding, Dong Qiu, Shang Yuchen Shi, Gang Wang, Lin Fang, Huizhong Li, Hui Tian, Jie Yang, Qing Zhang, Junnian Zheng. Co-immunization with L-Myc enhances CD8+or CD103+DCs mediated tumor-specific multi-functional CD8+T cell responses[J]. Cancer Sci.2021,00:1–15.
2.Dafei Chai*, Zichun Zhang , Shang Yuchen Shi, Dong Qiu, Chen Zhang, Gang Wang, Lin Fang, Huizhong Li, Hui Tian, Hailong Li, Junnian Zheng*. Absent in melanoma 2-mediating M1 macrophages facilitate tumor rejection in renal carcinoma. Transl Oncol. 2021,14(4):101018.
3.Dafei Chai,Zichun Zhang,Shang Yuchen Shi,Dong Qiu,Chen Zhang,Gang Wang,Lin Fang,Huizhong Li,Hui Tian,Hailong Li,JunnianZheng*. Absent in melanoma 2 enhances anti-tumour effects of CAIX promotor controlled conditionally replicative adenovirus in renal cancer[J]. J CellMol Med, 2020, 24(18): 10744-10755.
4.Dafei Chai, Hongjian Shan, Gang Wang, Qing Zhang, Huizhong Li, Lin Fang, Jingyuan Song, Nianli Liu, Qian Zhang, Hong Yao, Junnian Zheng*. Combining DNA vaccine and AIM2 in H1 nanoparticles exert anti-renal carcinoma effects via enhancing tumor-specific multi-functional CD8+T cell responses[J]. Mol Cancer Ther, 2019, 18(2): 323-334.
5.Dafei Chai, Hongjian Shan, Gang Wang, Huizhong Li, Lin Fang, Jingyuan Song, Qing Zhang, Jin Bai, Junnian Zheng*. AIM2 is a potential therapeutic target in human renal carcinoma and suppresses its invasion and metastasis via enhancing autophagy induction[J]. Exp Cell Res, 2018, 370(2): 561-570.
6.Dafei Chai, Yan Yue , Wei Xu, Chunsheng, Dong, & Xiong, Sidong*. AIM2 co-immunization favors specific multifunctional CD8+T cell induction and ameliorates coxsackievirus B3-induced chronic myocarditis. Antiviral Res, 2015, 119: 68-77.
7. Dafei Chai, Yan Yue, Wei Xu, Chunsheng Dong, & Xiong Sidong*. Mucosal co-immunization with AIM2 enhances protective SIgA response and increases prophylactic efficacy of chitosan-DNA vaccine against coxsackievirus B3-induced myocarditis. Hum Vacc Immunother, 2014, 10(5): 1284-1294.
8. Yan Luan,Dafei Chai,Jianjian Peng, Shuli Ma, Min Wang, Hui Ma, Xiang Shilong Li, Fu Pan Xiaolong Wang Xiaoxiao,Qin Songbin, & Xu Ting*. A fully human monoclonal antibody targeting PD-L1 with potent anti-tumor activity. Int Immunopharmcol[J]. 2016, 31, 248-256.
