电子邮箱：sssun@xzhmu.edu.cn
孙世硕，博士，副教授。
2018年6月获苏州大学医学博士学位，师从苏雄教授；2022年12月至2023年12月于瑞典卡罗琳斯卡医学院访问交流，合作导师曹义海院士。
目前主要从事肿瘤免疫微环境以及CAR-T细胞代谢与功能调控的机制研究。近3年以第一/共一及通讯作者在Cancer Immunol Res、Cancer Lett等期刊发表SCI论文10篇；主持国家自然科学基金、江苏省高等学校自然科学基金、徐州市科技计划项目等5项。
研究方向：肿瘤微环境与CAR-T细胞治疗
代表论文：
1.Ziheng Guo#, Xu Jing#, Xiaoting Sun#,Shishuo Sun#, Yunlong Yang#, Yihai Cao*. Tumor angiogenesis and anti-angiogenic therapy.Chin Med J (Engl).2024 Jul 25.
2.Wanxin Zhao#, Yizhou Yao#, Qihong Li, Ying Xue, Xiaoge Gao, Xiangye Liu, Qing Zhang*, Junnian Zheng*,Shishuo Sun*. Molecular mechanism of co-stimulatory domains in promoting CAR-T cell anti-tumor efficacy.Biochem Pharmacol.2024 Sep;227:116439.
3.Shishuo Sun#, Heng Xu#, Wanxin Zhao, Qihong Li, Yifan Yuan, Guopeng Zhang, Shuyu Li, Bixi Wang, Wei Zhang, Xiaoge Gao, Junnian Zheng*,Qing Zhang*. PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt/mTOR-mediated Ca2+ flux.Cancer Lett. 2024 Jan 28:581:216511.
4.Shishuo Sun#, Chao Huang#, Mengmeng Lu#, Heng Xu, Yifan Yuan, Wanxin Zhao, Xiaolei Hu, Bixi Wang, Wei Zhang, Xiaoge Gao, Junnian Zheng*, Lishan Su*,Qing Zhang*. Herpes virus entry mediator costimulation signaling enhances CAR-T cell efficacy against solid tumors through metabolic reprogramming.Cancer Immunol Res. 2023, 11(4):515-529.
5.Shishuo Sun#, Yizhou Yao#, Chao Huang#, Heng Xu, Yuxiao Zhao, Yifei Wang, Yizhang Zhu, Yangna Miao, Xinhui Feng, Xiaoge Gao, Junnian Zheng*, Qing Zhang*. CD36 regulates LPS-induced acute lung injury by promoting macrophages M1 polarization.Cell Immunol. 2022 Feb:372:104475.
6.Yizhou Yao#,Shishuo Sun#, Jinrong Gu, Haishun Ni, Kaiqiang Zhong, Qixuan Xu, Diyuan Zhou, Xuchao Wang, Ling Gao, Xinguo Zhu. Roux-en-Y reconstruction alleviates radical gastrectomy-induced colitis via down-regulation of the butyrate/NLRP3 signaling pathway.EBioMedicine. 2022 Dec:86:104347.
7.Xinyu Shao#,Shishuo Sun#, Yuqing Zhou, Huiyu Wang, Yang Yu, Tong Hu, Yizhou Yao*, Chunli Zhou*.Bacteroides fragilis restricts colitis-associated cancer via negative regulation of the NLRP3 axis.Cancer Lett. 2021 Dec 28:523:170-181.
