李建杰，博士，徐州医科大学江苏省肿瘤生物治疗研究所讲师，2022年1月毕业于澳门大学健康科学学院，获得生物医药博士学位。同年6月加入肿瘤所。

主要从事溶瘤病毒抗肿瘤的免疫调控、靶向诱导肿瘤细胞融合抗肿瘤和溶瘤病毒为递送载体的抗实体瘤的研究。以第一或共同作者在Nature Communications、 JCI、Cancer Research和Theranostics等发表多篇SCI论文。

代表论文：

[1]J. Li, X. Shu, J. Xu, S.M. Su, U.I. Chan, L. Mo, J. Liu, X. Zhang, R. Adhav, Q. Chen, Y. Wang, T. An, X. Zhang, X. Lyu, X. Li, J.H. Lei, K. Miao, H. Sun, F. Xing, A. Zhang, C. Deng, X. Xu, S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy, Nat Commun, 13 (2022) 1481.

[2] J. Xu, S.M. Su, X. Zhang, U.I. Chan, R. Adhav, X. Shu, J. Liu, J. Li, L. Mo, Y. Wang, T. An, J.H. Lei, K. Miao, C.X. Deng, X. Xu, ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine, J Clin Invest, 132 (2022).

[3] J. Liu, R. Adhav, K. Miao, S.M. Su, L. Mo, U.I. Chan, X. Zhang, J. Xu, J. Li, X. Shu, J. Zeng, X. Zhang, X. Lyu, L. Pardeshi, K. Tan, H. Sun, K.H. Wong, C. Deng, X. Xu, Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor, Nat Commun, 11 (2020) 4875.

[4] F. Xing, Y.C. Liu, S. Huang, X. Lyu, S.M. Su, U.I. Chan, P.C. Wu, Y. Yan, N. Ai, J. Li, M. Zhao, B.K. Rajendran, J. Liu, F. Shao, H. Sun, T.K. Choi, W. Zhu, G. Luo, S. Liu, L. Xu, K.L. Chan, Q. Zhao, K. Miao, K.Q. Luo, W. Ge, X. Xu, G. Wang, T.M. Liu, C.X. Deng, Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform, Theranostics, 11 (2021) 9415-9430.

[5]Shu X, Li J, Chan UI, Su SM, Shi C, Zhang X, An T, Xu J, Mo L, Liu J, Wang Y, Li X, Deng M, Lei JH, Wang C, Tian H, Sun H, Shim JS, Zhang X, Dai Y, Yao Z, Kuang X, Lin Y, Deng CX, Xu X. BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment that Promotes Metastasis and Immunotherapy Resistance. Cancer Res. 2023 May 25:CAN-22-3398. doi: 10.1158/0008-5472.CAN-22-3398. Epub ahead of print. PMID: 37227919.