研究成果：
1.Lu Hu *,Yang Sun*, Shun Liu *(equal to this work) , Hannah Erb, Alka Singh, Junhao Mao, Xuelian Luo, Xu Wu. Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode.Elife.2022, 11:e80210.
2.Yang Sun*#（corresponding author）, Lu Hu#, Zhipeng Tao#, Gopala K Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L. Cotton, Patricia Greninger, Regina K. Egan, Y. Tony Ip, Cyril H. Benes, Jianwei Che, Junhao Mao*, Xu Wu*, Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells.Nature Communications.2022, 13(1):6744.
3.Qi Li*,Yang Sun*, Gopala K. Jarugumilli* (equal to this work), Shun Liu, Kyvan Dang, Jennifer L. Cotton, Jordi Xiol, Pui Yee Chan, Michael DeRan, Lifang Ma1, Rui Li, Lihua J. Zhu, Joyce H. Li, Andrew B. Leiter, Y. Tony Ip, Fernando D. Camargo, Xuelian Luo, Randy L. Johnson, Xu Wu, Junhao Mao. Lats1/2 sustain intestinal stem cells through Tead-dependent and -independent transcription.Cell Stem Cell. 2020, 26(5):675-692.
4.Yang Sun*, Feng Guo*, Zhen Zou*, Chenggang Li*, Xiaoxu Hong*, Yan Zhao* (equal to this work), Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo, Dangsheng Li, Bo Li, Qihan Li, Nanshan Zhong, Chen Wang, Josef M Penninger and Chengyu Jiang. Cationic nanoparticles bind angiotensin-converting enzyme 2 directly and induce mice acute lung injury.Particle and Fibre Toxicology.2015, 12:4
5.Yang Sun, Erik Zhang, Tasha Morrison, Chenggang Li and Jane J. Yu. Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis.Hormones and Cancer2014, 5, 284–298
6.Yang Sun, Dana Gallacchi, Erik Y. Zhang, Samuel B. Reynolds, Lauren Robinson, Izabella A. Malinowska, Terry T. Chiou, Ana M. Pereira, Chenggang Li, David J. Kwiatkowski, Po-Shun Lee, and Jane J. Yu. Rapamycin-resistant PARP1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis (LAM).American Journal of Respiratory Cell and Molecular Biology. 2014, 51(6):738-49
7.Yang Sun, Xiaoxiao Gu, Erik Zhang, Mi-Ae Park, Ana M. Pereira, Shuyan Wang, Tasha Morrison, Chenggang Li, John Blenis, Victor H. Gerbaudo1, Elizabeth Petri Henske, and Jane J. Yu. Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.Cell Death and Disease.2014, 5(5):e1231
8.Chenggang Li§, Po-Shun Lee§Yang Sun§,(equal to this work), Xiaoxiao Gu, Erik Zhang, Yanan Guo, Chin-Lee Wu, Neil Auricchio, Carmen Priolo, Jing Li, Alfredo Csibi, Andrey Parkhitko, Tasha Morrison, Anna Planaguma, Shamsah Kazani, Elliot Israel, Kai-Feng Xu, Elizabeth Petri Henske, John Blenis, Bruce D. Levy, David Kwiatkowski, Jane J. Yu. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.Journal of Experimental Medicine. 2014, 211(1):15-28.
9.Yang Sun§, Chenggang Li§, Yuelong Shu§(equal to this work), Xiangwu Ju, Zhen Zou, Hongliang Wang, Shuan Rao, Feng Guo, Haolin Liu, Wenlong Nan, Yan Zhao, Yiwu Yan, Jun Tang, Chen Zhao, Peng Yang, Kangtai Liu, Shunxin Wang, Huijun Lu, Xiao Li, Lei Tan, Rongbao Gao, Jingdong Song, Xiang Gao, Xinlun Tian, Yingzhi Qin, Kaifeng Xu, Dangsheng Li, Ningyi Jin, Chengyu Jiang. Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection in Mice.Science signaling2012, 21;5(212):ra16.
10.Chenggang Li§, Penghui Yang§,Yang Sun§, (equal to this work), Taisheng Li, Chen Wang, Zhong Wang, Zhen Zou, Chen Wang, Zhongwei Chen, Li Xing, Chong Tang, Xiangwu Ju, Feng Guo, Jiejie Deng, Yan Zhao, Yiwu Yan, Peng Yang, Jun Tang, Huanling Wang, Zhongpeng Zhao, Zhinan Yin, Dangsheng Li, Bin Cao, Xiliang Wang, Chengyu Jiang. IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus.Cell Research.2011, 22(3):528-38
11.Chenggang Li§, Haolin Liu§,Yang Sun§(equal to this work), Hongliang Wang, Feng Guo, Shuan Rao, Jiejie Deng, Yanli Zhang, Yufa Miao, Chenying Guo, Jie Meng, Xiping Chen, Limin Li, Dangsheng Li, Haiyan Xu, Heng Wang, Bo Li and Chengyu Jiang. PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway.Journal of Molecular Cell Biology2009,1(1):37-45.
12.Zhipeng Tao,Yang Sun, Baoen Chen, Carla Guarino, Hannah Erb, Junhao Mao, Xu Wu. ABHD1/12-mediated TEADs depalmitoylation regulates Hippo pathway transcriptional output. FASEB Journal 2021, 35(S1)
13.Jennifer L. Cotton , Kyvan Dang , Lu Hu,Yang Sun, Alka Singh, Mihir S. Rajurkar, Qi Li, Xu Wu, Junhao Mao. PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis.Cell Reports. 2022,40(3):111125.
14.Huapeng Li , Qi i , Kyvan Dang , Shan Ma , Jennifer L Cotton,Yang Sun, Lihua J Zhu, April C Deng, Y Tony Ip, Randy L Johnson, Xu Wu , Claudio Punzo, Junhao Mao. YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression.Cell Reports. 2019, 29(10):3200-3211.
15.Baoen Chen,Yang Sun, Jixiao Niu, Gopala K. Jarugumilli, Xu Wu. Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities.Cell Chemical Biology.2018, 25(7):817-831
16.Gopala Krishna Jarugumilli, Jong-Ryoul Choi, PuiYee Chan, Meilan Yu,Yang Sun, Baoen Chen, Jixiao Niu, Michael DeRan, Baohui Zheng, Raphael Zoeller, Cheng Lin, and Xu Wu. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal.ACS Chemical Biology. 2018, 13(5):1130-1136.
17.Chenggang Li, Xiaolei Liu, Yang Liu, Erik Zhang, Kantha Medepalli, Kouhei Masuda, Na Li, Kathryn A Wikenheiser-Brokamp, Andrew Osterburg, Michael T Borchers, Elizabeth J Kopras, David R Plas, Julia Sun, David N Franz, Jamie K Capal, Maxwell Mays,Yang Sun, David J Kwiatkowski, Anya Alayev, Marina K Holz, Darcy A Krueger, Brian J Siroky, J Yu Jane. Tuberin Regulates Prostaglandin Receptor–Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.Molelular Cancer Research. 2017,15(10):1318-1330.
18.Chenggang Li, Na Li, Xiaolei Liu, Erik Y. Zhang,Yang Sun, Kouhei Masuda,Jing Li,Julia Sun, Tasha Morrison, Xiangke Li, Yuanguang Chen, Jiang Wang, Nagla A. Karim, Yi Zhang,John Blenis, Mauricio J. Reginato, Elizabeth P. Henske, and Jane J. Yu. Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.JCI Insight. 2016, 1(19):e86629
19.A.A. Goldberg , Kwang-bo Joung, Asma Mansuri, Yujin Kang, R. Echavarria , L. Nikolajev ,Yang Sun, Jane. J. Yu , S.A. Laporte , A. Schwertani , Arnold S. Kristof. Oncogenic Effects of Urotensin-II in Cells Lacking Tuberous Sclerosis Complex-2.Oncotarget.2016, 7(38):61152-61165.
20.Jing Li, Sejeong Shin,Yang Sun, Sang-Oh Yoon, Chenggang Li, Erik Zhang, Jane Yu, Jianming Zhang, John Blenis. mTORC1-driven tumor cells are highly sensitive to therapeutic targeting by antagonists of oxidative stress.Cancer Research.2016, pii: canres.2629.2015.
21.Zhiqiang Jiang, Taotao Lao, Weiliang Qiu, Francesca Polverino, Kushagra Gupta, Feng Guo, John Mancini, Michael Cho, Peter Castaldi,Yang Sun, Jane Yu, Maria Laucho-Contreras, Lester Kobzik, Benjamin Raby, Choi Augustine, Mark Perrella, Caroline Owen, Edwin Silverman, and Xiaobo Zhou. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Stability of β-catenin.American Journal of Respiratory and Critical Care Medicine. 2016, 194(2):185-97
22.Subrata Manna, Josefine Bostner,Yang Sun, Lance D. Miller, Anya Alayev, Rachel S. Salamon, Elin Lager, Tommy Fornander, Bo Nordenskjöld, Jane J. Yu, Olle Stål2, Marina K. Holz. ERRα regulates sensitivity to rapamycin via changes in S6K1 expression, and tamoxifen sensitivity and survival in triple-negative breast cancer.Clinical Cancer Research.2015 pii: clincanres.0857.2015
23.Adi Y Berman, Subrata Manna, Naomi S Schwartz, Yardena E Katz,Yang Sun, Catherine A Behrmann, Jane J Yu, David R Plas, Anya Alayev, Marina K Holz.ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism.Signal Transduction Target Therapy. 2017;2:e17035.
24.Anya Alayev , Rachel S Salamon ,Yang Sun, Naomi S Schwartz , Chenggang Li , Jane J Yu , Marina K Holz.Effects of Combining Rapamycin and Resveratrol on Apoptosis and Growth of TSC2-Deficient Xenograft Tumors.American Journal of Respiratory Cell and Molecular Biology2015, 53(5):637-46
25.Chenchen Feng,Yang Sun, Guanxiong Ding, Zhong Wu, Haowen Jiang, Lujia Wang, Qiang Ding, Hui Wen. PI3Kβ Inhibitor TGX221 Selectively Inhibits Renal Cell Carcinoma Cells with Both VHL and SETD2 mutations and Links Multiple Pathways.Scientific Reports.2015, 5:9465.
26.Doug Medvetz,Yang Sun, Chenggang Li, Damir Khabibullin, Murugabaskar Balan, Andrey Parkhitko, Carmen Priolo, John Asara, Soumitro Pal2, Jane Yu, and Elizabeth P. Henske. High-throughput chemical screening identifies chelerythrine chloride as a selective inducer of death in TSC2-null cells.Molecular Cancer Research.2014, 13(1):50-62.
27.Chenggang Li, Erik Zhang,Yang Sun, Po-Shun Lee, Yongzhong Zhan, Yanan Guo, Juan Osorio, Ivan O. Rosas, David J. Kwiatkowski and Jane J. Yu. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis complex and lymphangioleiomyomatosis.PLoS ONE. 2014 Oct 27;9(10):e104809
28.Zhen Zou§, Yiwu Yan§, Yuelong Shu§, Rongbao Gao§, (equal to this work) Yang Sun, Xiao Li, Xiangwu Ju, Zhu Liang, Qiang Liu, Yan Zhao, Feng Guo, Tian Bai, Zongsheng Han, Jindong Zhu, Huandi Zhou, Fengming Huang, Chang Li, Huijun Lu, Ning Li, Dangsheng Li, *Ningyi Jin, *Josef M. Penninger, Chengyu Jiang. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.Nature Communications. 2014, 5:3594.
29.Anya Alayev,Yang Sun, Rose B Snyder, Sara Malka Berger, Jane J Yu, Marina K Holz. Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells.Cell Cycle. 2014 ,13(3):371-82.
30.Chenggang Li, Xiaobo Zhou,Yang Sun, Erik Zhang, John D Mancini, Andrey Parkhitko, Tasha A Morrison, Edwin K Silverman, Elizabeth P Henske, Jane J Yu. Faslodex Inhibits Estradiol-Induced Extracellular Matrix Dynamics and Lung Metastasis in a Model of Lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology.2013 ,49 (1), 135-142.
31.Yanli Zhang, Jiejie Deng, Yanxu Zhang, Feng Guo, Chenggang Li, Zhen Zou, Wen Xi, Jun Tang,Yang Sun, Peng Yang, Zongsheng Han, Dangsheng Li, Chengyu Jiang. Functionalized single-walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice.Journal of Molecular Medicine.2013, 91(1):117-28(IF=4.855)
32.Yiwu Yan§, Zhen Zou§(equal to this work),Yang Sun,Xiao Li, Kai-Feng Xu, Yuquan Wei, Ningyi Jin, Chengyu Jiang. Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.Cell Research.2013, 23(2):300-2.
33.Chenggang Li, Penghui Yang, Yanli Zhang,Yang Sun, Wei Wang, Zhen Zou, Li Xing, Zhongwei Chen, Chong Tang, Feng Guo, Jiejie Deng, Yan Zhao, Yiwu Yan, Jun Tang, Xiliang Wang, Chengyu Jiang. Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice.PLoS ONE.2012, 7(8):e44110.
34.Haolin Liu, Yanli Zhang, Ning Yang, Yanxu Zhang, Xiaoqin Liu, Chenggang Li, Yan Zhao, Yuguo Wang, Guigen Zhang, Peng Yang, Feng Guo,Yang Sun, Chengyu Jiang. A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling.Cell Death and Disease.2011, 2, e159
35.Yumiko Imai, Keiji Kuba, G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria Ermolaeva,Ruud Veldhuizen, Y.H. Connie Leung, Hongliang Wang, Haolin Liu,Yang Sun, Manolis Pasparakis, Manfred Kopf,Christin Mech,Sina Bavari,J.S. Malik Peiris,Arthur S. Slutsky, Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John Nicholls,Chengyu Jiang,Christoph J. Binder,and Josef M. Penninger. Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury.Cell.2008, 133, 235–249.
