江苏省特聘教授

果春青，博士，教授，博士生导师。2008年毕业于北京师范大学细胞生物学专业获理学博士学位。2008年至2015年在美国Roswell Park Comprehensive Cancer Center和Virginia Commonwealth University Massey Cancer Center从事博士后研究。2015年至2023年在美国Virginia Commonwealth University Massey Cancer Center先后任讲师，助理教授。长期从事肿瘤免疫学研究，在PNAS, Hepatology, Nature Communications, Cancer Research和Annals of Rheumatic Diseases等国际知名刊物上发表学术论文60余篇，成果被引用近3000次。在美国工作期间承担及参与American Cancer Society，National Institute of Health，National Cancer Institute多项重大课题。2023年入选江苏省特聘教授，加入徐州医科大学肿瘤生物治疗国家地方联合工程实验室，建立肿瘤免疫治疗研究组。目前课题组研究获得国家自然科学基金、江苏省特聘教授人才项目和徐州医科大学优秀人才启动项目的支持。

研究方向：

（1）肿瘤微环境中影响树突状细胞（dendritic cell）交叉递呈肿瘤抗原的机制研究；

（2）树突状细胞作为肿瘤疫苗在肿瘤治疗中的应用；

（3）从表观遗传学角度探索优化肿瘤TCR-T和CAR-T疗法。

联系方式：guochunqing2023@outlook.com

代表性论文：

1. Liu Z., Liu W., Wang W., Ma Y., Wang Y., Drum D.L., Cai J., Blevins H., Lee E., Shah S., Fisher P.B., Wang X., Fang X.,*Guo C.,* Wang XY.* CPT1A-mediated fatty acid oxidation confers cancer cell resistance to immune-mediated cytolytic killing. Proc Natl Acad Sci USA. (2023)*Corresponding authors

2.Guo C.,* Liu W., Liu Z., Yu X, Wang H., Li X., Zuo D., Jiang X., Zhang B, Liu J., Sanyal A., Puri P., Zhou H., and Wang X.Y.* Scavenger Receptor A Is a Major Homeostatic Regulator that Restrains Drug-Induced Liver Injury. Hepatology (2023). *Corresponding authors

3. Yu, X., Liu, W., Chen, S., Cheng, X., Paez, P.A., Sun, T., Yuan, F., Wei, C., Landry, J.W., Poklepovic, A.S., Bear, H.D., Subjeck, J.R., Repasky, E.,Guo, C. *& Wang, X.Y.* Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity. Journal for immunotherapy of cancer (2021).* Corresponding authors

4. Liu, Z.,Guo, C.(equal contribution), Das, S., Yu, X., Pradhan, A.K., Li, X., Ning, Y., Chen, S., Liu, W., Windle, J.J., Bear, H.D., Manjili, M.H., Fisher, P.B. & Wang, X.Y. Enhancing cancer immunotherapy by engineering T cells to express tumoricidal MDA-7/IL-24. Cancer Research (2021).

5. Hu, F., Jiang, X.,Guo, C.(equal contribution), Li, Y., Chen, S., Zhang, W., Du, Y., Wang, P., Zheng, X., Fang, X., Li, X., Song, J., Xie, Y., Huang, F., Xue, J., Bai, M., Jia, Y., Liu, X., Ren, L., Zhang, X., Guo, J., Pan, H., Su, Y., Yi, H., Ye, H., Zuo, D., Li, J., Wu, H., Wang, Y., Li, R., Liu, L., Wang, X.Y. & Li, Z. Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study. Nature Communications (2020).

6. Wang, J.,Guo, C.(equal contribution), Wang, X.Y. & Yang, H. Double-punch" strategy for delivery of viral immunotherapy with prolonged tumor retention and enhanced transfection efficacy. Journal of controlled release (2020).

7. Chen, S.,Guo, C.(equal contribution), Wang, R., Feng, Z., Liu, Z., Wu, L., Zhao, D., Zheng, S., Chen, F., Zhang, D., Xu, J., Zhu, J., Chen, X., Li, Z., Wise, C.M., Li, J. & Wang, X.-Y. Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis. Rheumatology (2020).

8.Guo, C., Hu, F., Yi, H., Feng, Z., Li, C., Shi, L., Li, Y., Liu, H., Yu, X. & Wang, H. Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis. Annals of the rheumatic diseases (2016).

代表性论著

1.Guo C, Harris T, Wang X-Y. Aiming the Immune System to Improve the Antitumor Efficacy of Radiation Therapy. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment: Springer, Cham; 2016. p 159-81.

2.Guo C, Subjeck, JR, Wang XY. Creation of recombinant chaperone vaccine using large heat shock protein for antigen-targeted cancer immunotherapy.Molecular Chaperones: Methods and Protocols.Methods in Molecular Biology. Editors: Calderwood, Stuart K., Prince, Thomas L. (Eds.). Humana Press 2017; p277-287. ISBN 978-1-61779-295-3